Clomipramine withdrawal in newborns

[Nicotine withdrawal symptoms in newborns].

Clomipramine concentration and withdrawal symptoms in 10 neonates.

AIM After in utero exposure to tricyclic antidepressants, neonatal withdrawal symptoms have been reported with an estimated incidence between 20 and 50%; however, few data are available for clomipramine. This could also be the case for neonatal pharmacokinetic clomipramine parameters and so this study was set up. METHODS Babies exposed to clomipramine in utero were included in an observationa...

SSRI Antidepressant Withdrawal Syndrome in Newborns

Editor’s Note: Adverse drug reactions experienced by UWMC or HMC patients and reported to the pharmacy are reviewed quarterly by the Pharmacy & Therapeutics Committee. Following the Committee’s review, a summary is published in this newsletter (see page 9) along with a companion article regarding some aspect of adverse drug reactions. It is hoped that these articles will be useful tools to remi...

Noninitiation or withdrawal of intensive care for high-risk newborns.

Advances in medical technology have led to dilemmas in initiation and withdrawal of intensive care of newborn infants with a very poor prognosis. Physicians and parents together must make difficult decisions guided by their understanding of the child's best interest. The foundation for these decisions consists of several key elements: (1) direct and open communication between the health care te...

Measurement of clomipramine, N-desmethyl-clomipramine, imipramine, and dehydroimipramine in biological fluids by selective ion monitoring, and pharmacokinetics of clomipramine.

To quantitatively determine tricyclic antidepressant agents, we used a combined gas chromatograph/mass spectrometer system, and deuterium-labeled internal standards. Recovery exceeds 95% and the coefficient of variation is less than 4% for human whole-blood samples supplemented with 5 to 15 ng of clomipramine hydrochloride or 20 to 60 ng of dehydroimipramine hydrogen fumarate per milliliter. Fo...